Our research strategy is underpinned by our expertise in personalised medicine, uterine physiology and research synthesis. We are convinced that progress in preterm birth research requires blending of multiple omics platforms with functional testing and research synthesis. Our personalised medicine approach will use biochemical information from pregnant women to precisely tailor their healthcare provision. Our interconnected research programmes are directed at gaining increased understanding of aetiology and mechanisms of preterm birth and aim to provide leading-edge research training for early career researchers committed to preterm birth research.
Genetic and metabolomic approach to preterm birth phenotyping
Our goal is to enable sophisticated biomarker phenotyping leading to personalised risk assessment in early pregnancy and better and safer use of preventative therapies. We will use high-throughput technologies to examine simultaneously millions of genes, transcripts and metabolites in an unbiased "hypothesis generating, multi layering" approach in women who suffered spontaneous preterm birth. We will then validate predictive value of these preterm birth gene/multifactorial/systematic signatures in low risk women.
Developing more effective tocolytic regimens
We will elucidate the contribution of uterine environment and gestation on tocolytic efficacy by using a range of technique, including imaging, metabolomics and transcriptomics, to determine key pathways and molecula events, allowing us to identify novel tocolytic targets.
Evaluating different preventative strategies by research synthesis - global approach
Liverpool is an acknowledged world leader in research synthesis. By pioneering methods such as network meta-analysis, along with national and international collaborations, including RCOG, NICE and WHO, the best insights into effective preventative strategies will arise. Our Harris-Wellbeing of Women (WoW) Research Centre will become the international reference centre for research synthesis related to preterm birth.
1. The LifeStart Trolley - the development and testing of a bedside neonatal resuscitation unit.
2. The BabySaver Tray - the development and testing of a low cost bedside neonatal resuscitation unit.
3. The BabyGel study - evaluation of alcohol-based hand rub for the prevention of newborn sepsis in rural Uganda.
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